Skin: Grade 1: dull erythema, decreased sweating. Grade 2: moderate edema, bright erythema, pitting edema Grade 4″ Ulceration, hemorrhage and necrosis.

Mucous membrane: Grade 1:mild pain at injection site Grade2:inflammatory serosanguinous discharge Grade 3:confluent fibrinous mucositis Grade 4: Unceration, hemarhhage or necrosis.

Eye: Grade 1: mild conjuctivits, grade2: moderate conjuctivits  grade3: sevre keratitis ,acute glaucoma Grade4: loss opf vision.